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Furoxans (1, 2, 5 Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents

Furoxans (1,2,5 oxadiazole-N-oxides) are thiol-bioactivated NO-mimetics that have not hitherto been studied in the CNS. Incorporation of varied substituents adjacent to the furoxan ring system led to modulation of reactivity towards bioactivation, studied by HPLC-MS/MS analysis of reaction products....

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Main Authors: Schiefer, Isaac T., VandeVrede, Lawren, Fa', Mauro, Arancio, Ottavio, Thatcher, Gregory R. J.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407596/
https://ncbi.nlm.nih.gov/pubmed/22429006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201504s
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