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Furoxans (1, 2, 5 Oxadiazole-N-Oxides) as Novel NO Mimetic Neuroprotective and Procognitive Agents
Furoxans (1,2,5 oxadiazole-N-oxides) are thiol-bioactivated NO-mimetics that have not hitherto been studied in the CNS. Incorporation of varied substituents adjacent to the furoxan ring system led to modulation of reactivity towards bioactivation, studied by HPLC-MS/MS analysis of reaction products....
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3407596/ https://ncbi.nlm.nih.gov/pubmed/22429006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201504s |
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