Reduced Posterior Cingulate Mitochondrial Activity in Expired Young Adult Carriers of the APOE ε4 Allele, the Major Late-Onset Alzheimer's Susceptibility Gene

In vivoPET imaging studies of young-adult carriers of the apolipoprotein E ε4 allele (APOEε4), the major Alzheimer's disease (AD) susceptibility gene, have demonstrated declines in glucose metabolism in brain areas later vulnerable to AD, such as posterior cingulate cortex, decades before the p...

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Hlavní autoři: Valla, Jon, Yaari, Roy, Wolf, Andrew B., Kusne, Yael, Beach, Thomas G., Roher, Alex E., Corneveaux, Jason J., Huentelman, Matthew J., Caselli, Richard J., Reiman, Eric M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124564/
https://ncbi.nlm.nih.gov/pubmed/20847408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-100129
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