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A functional channel is necessary for growth suppression by Cx37

Connexin 37 (Cx37) profoundly suppresses the proliferation of rat insulinoma (Rin) cells by unknown mechanisms. To determine whether a functional pore domain is necessary for Cx37-mediated growth suppression, we introduced a mutation that converted threonine 154 into alanine (T154A). Like other conn...

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Hlavní autoři: Good, Miranda E., Nelson, Tasha K., Simon, Alexander M., Burt, Janis M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Company of Biologists 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124374/
https://ncbi.nlm.nih.gov/pubmed/21693589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.081695
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