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Structural Basis for a Lethal Mutation in U6 RNA(,)
U6 RNA is essential for nuclear pre-mRNA splicing and has been implicated directly in catalysis of intron removal. The U80G mutation at the essential magnesium binding site of the U6 3′ intramolecular stem–loop region (ISL) is lethal in yeast. To further understand the structure and function of the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3124365/ https://ncbi.nlm.nih.gov/pubmed/12578359 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi027137h |
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