K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder

The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a ‘driver’ of UCC, we targeted the expression of mutated Fgfr3 to the murine urothelium using Cre-loxP...

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Detalhes bibliográficos
Main Authors: Ahmad, Imran, Singh, Lukram Babloo, Foth, Mona, Morris, Carol-Ann, Taketo, Makoto Mark, Wu, Xue-Ru, Leung, Hing Y., Sansom, Owen J., Iwata, Tomoko
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2011
Assuntos:
Research Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124065/
https://ncbi.nlm.nih.gov/pubmed/21504907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.006874
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