β-Catenin Activation Synergises with PTEN Loss to Cause Bladder Cancer Formation

Although deregulation of the Wnt signalling pathway has been implicated in urothelial cell carcinoma (UCC), the functional significance is unknown. To test its importance, we have targeted expression of an activated form of β-catenin to the urothelium of transgenic mice using Cre-Lox technology (Uro...

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Detalhes bibliográficos
Main Authors: Ahmad, Imran, Morton, Jennifer P, Singh, Lukram Babloo, Radulescu, Sorina M, Ridgway, Rachel A, Patel, Satish, Woodgett, James, Winton, Douglas J, Taketo, Makato Mark, Wu, Xue-Ru, Leung, Hing Y, Sansom, Owen J
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044461/
https://ncbi.nlm.nih.gov/pubmed/20818428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.399
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