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β-Catenin Activation Synergises with PTEN Loss to Cause Bladder Cancer Formation
Although deregulation of the Wnt signalling pathway has been implicated in urothelial cell carcinoma (UCC), the functional significance is unknown. To test its importance, we have targeted expression of an activated form of β-catenin to the urothelium of transgenic mice using Cre-Lox technology (Uro...
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| Autori principali: | , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3044461/ https://ncbi.nlm.nih.gov/pubmed/20818428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.399 |
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