Lipopolysaccharide Renders Transgenic Mice Expressing Human Serum Amyloid P Component Sensitive to Shiga Toxin 2

Transgenic C57BL/6 mice expressing human serum amyloid P component (HuSAP) are resistant to Shiga toxin 2 (Stx2) at dosages that are lethal in HuSAP-negative wild-type mice. However, it is well established that Stx2 initiates extra-intestinal complications such as the haemolytic-uremic syndrome desp...

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Main Authors: Griener, Thomas P., Strecker, Jonathan G., Humphries, Romney M., Mulvey, George L., Fuentealba, Carmen, Hancock, Robert E. W., Armstrong, Glen D.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123346/
https://ncbi.nlm.nih.gov/pubmed/21731756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021457
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