Identification of the Allosteric Regulatory Site of Insulysin

BACKGROUND: Insulin degrading enzyme (IDE) is responsible for the metabolism of insulin and plays a role in clearance of the Aβ peptide associated with Alzheimer's disease. Unlike most proteolytic enzymes, IDE, which consists of four structurally related domains and exists primarily as a dimer,...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Noinaj, Nicholas, Bhasin, Sonia K., Song, Eun Suk, Scoggin, Kirsten E., Juliano, Maria A., Juliano, Luiz, Hersh, Louis B., Rodgers, David W.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123307/
https://ncbi.nlm.nih.gov/pubmed/21731629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020864
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