Chloride Channel (Clc)-5 Is Necessary for Exocytic Trafficking of Na(+)/H(+) Exchanger 3 (NHE3)

ClC-5, a chloride/proton exchanger, is predominantly expressed and localized in subapical endosomes of the renal proximal tubule. Mutations of the CLCN5 gene cause Dent disease. The symptoms of Dent disease are replicated in Clcn5 knock-out mice. Absence of ClC-5 in mice is associated with reduced s...

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Detalhes bibliográficos
Principais autores: Lin, Zhihong, Jin, Shi, Duan, Xiaohong, Wang, Tong, Martini, Sabrina, Hulamm, Phuson, Cha, Boyoung, Hubbard, Ann, Donowitz, Mark, Guggino, Sandra E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123051/
https://ncbi.nlm.nih.gov/pubmed/21561868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.224998
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