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Activated protein C up-regulates procoagulant tissue factor activity on endothelial cells by shedding the TFPI Kunitz 1 domain

Thrombin and activated protein C (APC) signaling can mediate opposite biologic responses in endothelial cells. Given that thrombin induces procoagulant tissue factor (TF), we examined how TF activity is affected by APC. Exogenous or endogenously generated APC led to increased TF-dependent factor Xa...

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Bibliografske podrobnosti
Main Authors: Schuepbach, Reto A., Velez, Kara, Riewald, Matthias
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122952/
https://ncbi.nlm.nih.gov/pubmed/21474669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-316257
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