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Coagulation factor Xa cleaves PAR1 and mediates signaling dependent on binding to the endothelial protein C receptor
BACKGROUND AND OBJECTIVE: Coagulation is intrinsically tied to inflammation and both pro- and anti-inflammatory responses are modulated by coagulation protease signaling through protease activated receptor-1 (PAR1). Activated factor X (Xa) can elicit cellular signaling through PAR1 but little is kno...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3103137/ https://ncbi.nlm.nih.gov/pubmed/19895674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2009.03682.x |
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