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Protease Activated Receptor-1 Cleaved at R46 Mediates Cytoprotective Effects

BACKGROUND: Activated protein C (aPC) mediates powerful cytoprotective effects through protease activated receptor (PAR)-1 that translate into reduced harm in mouse injury models. However, it remains elusive how aPC-activated PAR1 can mediate cytoprotective effects while thrombin activation does the...

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Bibliografiske detaljer
Main Authors: Schuepbach, Reto A., Madon, Jerzy, Ender, Miriam, Galli, Paolo, Riewald, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419798/
https://ncbi.nlm.nih.gov/pubmed/22712885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1538-7836.2012.04825.x
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