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Structure of γ-Secretase and Its Trimeric Pre-activation Intermediate by Single-particle Electron Microscopy
The γ-secretase membrane protein complex is responsible for proteolytic maturation of signaling precursors and catalyzes the final step in the production of the amyloid β-peptides implicated in the pathogenesis of Alzheimer disease. The incorporation of PEN-2 (presenilin enhancer 2) into a pre-activ...
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| Asıl Yazarlar: | , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2011
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3122203/ https://ncbi.nlm.nih.gov/pubmed/21454611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.193326 |
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