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Soluble oligomers of the intramembrane serine protease YqgP are catalytically active in the absence of detergents

Rhomboid, a polytopic membrane serine protease, represents a unique class of proteases that cleave substrates within the transmembrane domain. Elucidating the mechanism of this extraordinary catalysis comes with inherent challenges related to membrane-associated peptide hydrolysis. Here we establish...

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Détails bibliographiques
Auteurs principaux: Lei, Xiaojun, Ahn, Kwangwook, Zhu, Lei, Ubarretxena-Belandia, Iban, Li, Yue-Ming
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643057/
https://ncbi.nlm.nih.gov/pubmed/18937501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800385r
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