High-throughput Screening Uncovers a Compound That Activates Latent HIV-1 and Acts Cooperatively with a Histone Deacetylase (HDAC) Inhibitor

Current antiretroviral therapy (ART) provides potent suppression of HIV-1 replication. However, ART does not target latent viral reservoirs, so persistent infection remains a challenge. Small molecules with pharmacological properties that allow them to reach and activate viral reservoirs could poten...

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Autori principali: Micheva-Viteva, Sofiya, Kobayashi, Yoshifumi, Edelstein, Leonard C., Pacchia, Annmarie L., Lee, Hui-Ling Rose, Graci, Jason D., Breslin, Jamie, Phelan, Bradley D., Miller, Leia K., Colacino, Joseph M., Gu, Zhengxian, Ron, Yacov, Peltz, Stuart W., Dougherty, Joseph P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
Soggetti:
Gene Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122169/
https://ncbi.nlm.nih.gov/pubmed/21498519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.195537
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