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Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria

Lipid rafts and mitochondria are promising targets in cancer therapy. The synthetic antitumor alkyl-lysophospholipid analog edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) has been reported to target lipid rafts. Here, we have found that edelfosine induced loss of mitochondrial me...

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Bibliografiske detaljer
Main Authors: Mollinedo, F, Fernández, M, Hornillos, V, Delgado, J, Amat-Guerri, F, Acuña, A U, Nieto-Miguel, T, Villa-Pulgarín, J A, González-García, C, Ceña, V, Gajate, C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122120/
https://ncbi.nlm.nih.gov/pubmed/21593790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.41
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