Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria

Lipid rafts and mitochondria are promising targets in cancer therapy. The synthetic antitumor alkyl-lysophospholipid analog edelfosine (1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine) has been reported to target lipid rafts. Here, we have found that edelfosine induced loss of mitochondrial me...

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Detalhes bibliográficos
Main Authors: Mollinedo, F, Fernández, M, Hornillos, V, Delgado, J, Amat-Guerri, F, Acuña, A U, Nieto-Miguel, T, Villa-Pulgarín, J A, González-García, C, Ceña, V, Gajate, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122120/
https://ncbi.nlm.nih.gov/pubmed/21593790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.41
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