Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it

INTRODUCTION: To investigate the role of the low-density lipoprotein receptor-related protein 5 (Lrp5) in bones' responses to loading, we analysed changes in multiple measures of bone architecture in tibias subjected to loading or disuse in male and female mice with the Lrp5 loss of function mu...

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Main Authors: Saxon, Leanne K., Jackson, Brendan F., Sugiyama, Toshihiro, Lanyon, Lance E., Price, Joanna S.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Science 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121951/
https://ncbi.nlm.nih.gov/pubmed/21419885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2011.03.683
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