Interaction of survival of motor neuron (SMN) and HuD proteins with mRNA cpg15 rescues motor neuron axonal deficits

Spinal muscular atrophy (SMA), caused by the deletion of the SMN1 gene, is the leading genetic cause of infant mortality. SMN protein is present at high levels in both axons and growth cones, and loss of its function disrupts axonal extension and pathfinding. SMN is known to associate with the RNA-b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Akten, Bikem, Kye, Min Jeong, Hao, Le T., Wertz, Mary H., Singh, Sasha, Nie, Duyu, Huang, Jia, Merianda, Tanuja T., Twiss, Jeffery L., Beattie, Christine E., Steen, Judith A. J., Sahin, Mustafa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2011
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121858/
https://ncbi.nlm.nih.gov/pubmed/21652774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104928108
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