Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding

HuD protein (also known as ELAVL4) has been shown to stabilize mRNAs with AU-rich elements (ARE) in their 3′ untranslated regions (UTRs), including Gap43, which has been linked to axon growth. HuD also binds to neuritin (Nrn1) mRNA, whose 3′UTR contains ARE sequences. Although the Nrn1 3′UTR has bee...

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Vydáno v:J Cell Sci
Hlavní autoři: Gomes, Cynthia, Lee, Seung Joon, Gardiner, Amy S., Smith, Terika, Sahoo, Pabitra K., Patel, Priyanka, Thames, Elizabeth, Rodriguez, Reycel, Taylor, Ross, Yoo, Soonmoon, Heise, Tilman, Kar, Amar N., Perrone-Bizzozero, Nora, Twiss, Jeffery L.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702053/
https://ncbi.nlm.nih.gov/pubmed/28871047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.201244
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