Down-regulation of Hepatic Urea Synthesis by Oxypurines: XANTHINE AND URIC ACID INHIBIT N-ACETYLGLUTAMATE SYNTHASE

We previously reported that isobutylmethylxanthine (IBMX), a derivative of oxypurine, inhibits citrulline synthesis by an as yet unknown mechanism. Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylg...

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Autores principales: Nissim, Itzhak, Horyn, Oksana, Nissim, Ilana, Daikhin, Yevgeny, Caldovic, Ljubica, Barcelona, Belen, Cervera, Javier, Tuchman, Mendel, Yudkoff, Marc
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Metabolism
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121350/
https://ncbi.nlm.nih.gov/pubmed/21540182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.209023
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