3-Isobutylmethylxanthine Inhibits Hepatic Urea Synthesis: PROTECTION BY AGMATINE

We previously showed that agmatine stimulated hepatic ureagenesis. In this study, we sought to determine whether the action of agmatine is mediated via cAMP signaling. A pilot experiment demonstrated that the phosphodiesterase inhibitor, 3-isobutylmethylxanthine (IBMX), inhibited urea synthesis albe...

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Autors principals: Nissim, Itzhak, Horyn, Oksana, Nissim, Ilana, Daikhin, Yevgeny, Wehrli, Suzanne L., Yudkoff, Marc
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Metabolism and Bioenergetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397462/
https://ncbi.nlm.nih.gov/pubmed/18375388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800163200
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