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Down-regulation of Hepatic Urea Synthesis by Oxypurines: XANTHINE AND URIC ACID INHIBIT N-ACETYLGLUTAMATE SYNTHASE
We previously reported that isobutylmethylxanthine (IBMX), a derivative of oxypurine, inhibits citrulline synthesis by an as yet unknown mechanism. Here, we demonstrate that IBMX and other oxypurines containing a 2,6-dione group interfere with the binding of glutamate to the active site of N-acetylg...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3121350/ https://ncbi.nlm.nih.gov/pubmed/21540182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.209023 |
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