Reduced Bone Mass and Muscle Strength in Male 5α-Reductase Type 1 Inactivated Mice

Androgens are important regulators of bone mass but the relative importance of testosterone (T) versus dihydrotestosterone (DHT) for the activation of the androgen receptor (AR) in bone is unknown. 5α-reductase is responsible for the irreversible conversion of T to the more potent AR activator DHT....

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Main Authors: Windahl, Sara H., Andersson, Niklas, Börjesson, Anna E., Swanson, Charlotte, Svensson, Johan, Movérare-Skrtic, Sofia, Sjögren, Klara, Shao, Ruijin, Lagerquist, Marie K., Ohlsson, Claes
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120862/
https://ncbi.nlm.nih.gov/pubmed/21731732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021402
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