Reduced Bone Mass and Muscle Strength in Male 5α-Reductase Type 1 Inactivated Mice

Androgens are important regulators of bone mass but the relative importance of testosterone (T) versus dihydrotestosterone (DHT) for the activation of the androgen receptor (AR) in bone is unknown. 5α-reductase is responsible for the irreversible conversion of T to the more potent AR activator DHT....

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Bibliografiska uppgifter
Huvudupphovsmän: Windahl, Sara H., Andersson, Niklas, Börjesson, Anna E., Swanson, Charlotte, Svensson, Johan, Movérare-Skrtic, Sofia, Sjögren, Klara, Shao, Ruijin, Lagerquist, Marie K., Ohlsson, Claes
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2011
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120862/
https://ncbi.nlm.nih.gov/pubmed/21731732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021402
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