Liver-Derived IGF-I Regulates Mean Life Span in Mice

BACKGROUND: Transgenic mice with low levels of global insulin-like growth factor-I (IGF-I) throughout their life span, including pre- and postnatal development, have increased longevity. This study investigated whether specific deficiency of liver-derived, endocrine IGF-I is of importance for life s...

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Detalhes bibliográficos
Main Authors: Svensson, Johan, Sjögren, Klara, Fäldt, Jenny, Andersson, Niklas, Isaksson, Olle, Jansson, John-Olov, Ohlsson, Claes
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143189/
https://ncbi.nlm.nih.gov/pubmed/21799924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022640
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