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Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

The body growth of animals is regulated by growth hormone and IGF-I. The classical theory of this regulation is that most IGF-I in the blood originates in the liver and that body growth is controlled by the concentration of IGF-I in the blood. We have abolished IGF-I production in the livers of mice...

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Autors principals: Sjögren, Klara, Liu, Jun-Li, Blad, Kristina, Skrtic, Stanko, Vidal, Olle, Wallenius, Ville, LeRoith, Derek, Törnell, Jan, Isaksson, Olle G. P., Jansson, John-Olov, Ohlsson, Claes
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC22065/
https://ncbi.nlm.nih.gov/pubmed/10359843
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