Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis

We have shown previously that mutations in the apico-basal cell polarity regulators cooperate with oncogenic Ras (Ras(ACT)) to promote tumorigenesis in Drosophila melanogaster and mammalian cells. To identify novel genes that cooperate with Ras(ACT) in tumorigenesis, we carried out a genome-wide scr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Brumby, Anthony M., Goulding, Karen R., Schlosser, Tanja, Loi, Sherene, Galea, Ryan, Khoo, Peytee, Bolden, Jessica E., Aigaki, Toshiro, Humbert, Patrick O., Richardson, Helena E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Genetics Society of America 2011
Pynciau:
Investigations
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120157/
https://ncbi.nlm.nih.gov/pubmed/21368274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.127910
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