Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis

We have shown previously that mutations in the apico-basal cell polarity regulators cooperate with oncogenic Ras (Ras(ACT)) to promote tumorigenesis in Drosophila melanogaster and mammalian cells. To identify novel genes that cooperate with Ras(ACT) in tumorigenesis, we carried out a genome-wide scr...

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Détails bibliographiques
Auteurs principaux: Brumby, Anthony M., Goulding, Karen R., Schlosser, Tanja, Loi, Sherene, Galea, Ryan, Khoo, Peytee, Bolden, Jessica E., Aigaki, Toshiro, Humbert, Patrick O., Richardson, Helena E.
Format: Artigo
Langue:Inglês
Publié: Genetics Society of America 2011
Sujets:
Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120157/
https://ncbi.nlm.nih.gov/pubmed/21368274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.127910
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