Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis

We have shown previously that mutations in the apico-basal cell polarity regulators cooperate with oncogenic Ras (Ras(ACT)) to promote tumorigenesis in Drosophila melanogaster and mammalian cells. To identify novel genes that cooperate with Ras(ACT) in tumorigenesis, we carried out a genome-wide scr...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Brumby, Anthony M., Goulding, Karen R., Schlosser, Tanja, Loi, Sherene, Galea, Ryan, Khoo, Peytee, Bolden, Jessica E., Aigaki, Toshiro, Humbert, Patrick O., Richardson, Helena E.
Formato: Artigo
Idioma:Inglês
Publicado: Genetics Society of America 2011
Assuntos:
Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120157/
https://ncbi.nlm.nih.gov/pubmed/21368274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.127910
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares