Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis

We have shown previously that mutations in the apico-basal cell polarity regulators cooperate with oncogenic Ras (Ras(ACT)) to promote tumorigenesis in Drosophila melanogaster and mammalian cells. To identify novel genes that cooperate with Ras(ACT) in tumorigenesis, we carried out a genome-wide scr...

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Hlavní autoři: Brumby, Anthony M., Goulding, Karen R., Schlosser, Tanja, Loi, Sherene, Galea, Ryan, Khoo, Peytee, Bolden, Jessica E., Aigaki, Toshiro, Humbert, Patrick O., Richardson, Helena E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Genetics Society of America 2011
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Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3120157/
https://ncbi.nlm.nih.gov/pubmed/21368274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.127910
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