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The acetylation of tau inhibits its function and promotes pathological tau aggregation
The microtubule associated protein tau promotes neuronal survival through binding and stabilization of MTs. Phosphorylation regulates tau–microtubule interactions and hyperphosphorylation contributes to the aberrant formation of insoluble tau aggregates in Alzheimer’s disease (AD) and related tauopa...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3120096/ https://ncbi.nlm.nih.gov/pubmed/21427723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1255 |
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