The IGF-1R/IR Tyrosine Kinase Inhibitor, PQIP, Exhibits Enhanced Anti-Tumor Effects in Combination with Chemotherapy Against Colorectal Cancer Models

PURPOSE: There is growing evidence implicating the importance of the insulin-like growth factor (IGF) pathway in colorectal cancer (CRC) based upon the results of population studies, and preclinical experiments. However, the combination of an IGF-1 receptor (IGF-1R) inhibitor with standard CRC chemo...

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Hlavní autoři: Flanigan, Sara A., Pitts, Todd M., Eckhardt, S. Gail, Tentler, John J., Tan, Aik Choon, Thorburn, Andrew, Leong, Stephen
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3119523/
https://ncbi.nlm.nih.gov/pubmed/20943761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2054
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