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Facile Syntheses of O(2)-[4-(3-Pyridyl-4-oxobut-1-yl]thymidine, the Major Adduct Formed by Tobacco Specific Nitrosamine 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in vivo, and its Site-specifically Adducted Oligodeoxynucleotides
O(2)-[4-(3-Pyridyl)-4-oxobut-1-yl]thymidine (O(2)-POB-dThd) is the most persistent adduct detected in the lung and liver of rats treated with tobacco specific nitrosamines; N′-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3118900/ https://ncbi.nlm.nih.gov/pubmed/21524094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200127j |
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