Facile Syntheses of O(2)-[4-(3-Pyridyl-4-oxobut-1-yl]thymidine, the Major Adduct Formed by Tobacco Specific Nitrosamine 4-Methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in vivo, and its Site-specifically Adducted Oligodeoxynucleotides

O(2)-[4-(3-Pyridyl)-4-oxobut-1-yl]thymidine (O(2)-POB-dThd) is the most persistent adduct detected in the lung and liver of rats treated with tobacco specific nitrosamines; N′-nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3...

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Main Authors: Krishnegowda, Gowdahalli, Sharma, Arun K., Krzeminski, Jacek, Gowda, A.S. Prakasha, Lin, Jyh-Ming, Desai, Dhimant, Spratt, Thomas E., Amin, Shantu
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118900/
https://ncbi.nlm.nih.gov/pubmed/21524094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200127j
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