Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative

Recent studies have implicated an N-terminal caspase-6 cleavage product of mutant huntingtin (htt) as an important mediator of toxicity in Huntington's disease (HD). To directly assess the consequences of such fragments on neurologic function, we produced transgenic mice that express a caspase-...

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Main Authors: Tebbenkamp, Andrew T.N., Green, Cameron, Xu, Guilian, Denovan-Wright, Eileen M., Rising, Aaron C., Fromholt, Susan E., Brown, Hilda H., Swing, Debbie, Mandel, Ronald J., Tessarollo, Lino, Borchelt, David R.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118758/
https://ncbi.nlm.nih.gov/pubmed/21515588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr176
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