Chronic Exposure to a High-Fat Diet Induces Hepatic Steatosis, Impairs Nitric Oxide Bioavailability, and Modifies the Mitochondrial Proteome in Mice

Obesity-related pathologies, such as nonalcoholic fatty liver disease, are linked to mitochondrial dysfunction and nitric oxide (NO) deficiency. Herein, we tested the hypothesis that a high-fat diet (HFD) modifies the liver mitochondrial proteome and alters proteins involved in NO metabolism, namely...

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Detalhes bibliográficos
Main Authors: Eccleston, Heather B., Andringa, Kelly K., Betancourt, Angela M., King, Adrienne L., Mantena, Sudheer K., Swain, Telisha M., Tinsley, Heather N., Nolte, Ryan N., Nagy, Tim R., Abrams, Gary A., Bailey, Shannon M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Forum Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118652/
https://ncbi.nlm.nih.gov/pubmed/20919931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3395
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