Elevated serum IGF‐1 levels synergize PTH action on the skeleton only when the tissue IGF‐1 axis is intact

There is growing evidence that insulin‐like growth factor 1 (IGF‐1) and parathyroid hormone (PTH) have synergistic actions on bone and that part of the anabolic effects of PTH is mediated by local production of IGF‐1. In this study we analyzed the skeletal response to PTH in mouse models with manipu...

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Bibliographic Details
Main Authors: Elis, Sebastien, Courtland, Hayden‐William, Wu, Yingjie, Fritton, J Christopher, Sun, Hui, Rosen, Clifford J, Yakar, Shoshana
Format: Artigo
Language:Inglês
Published: Wiley Subscription Services, Inc., A Wiley Company 2010
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118256/
https://ncbi.nlm.nih.gov/pubmed/20499370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.100
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