Growth Hormone Mediates Pubertal Skeletal Development Independent of Hepatic IGF-1 Production

Deficiencies in either growth hormone (GH) or insulin-like growth factor 1 (IGF-1) are associated with reductions in bone size during growth in humans and animal models. Liver-specific IGF-1-deficient (LID) mice, which have 75% reductions in serum IGF-1, were created previously to separate the effec...

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Autores principales: Courtland, Hayden-William, Sun, Hui, Beth-On, Mordechay, Wu, Yingjie, Elis, Sebastien, Rosen, Clifford J, Yakar, Shoshana
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3179330/
https://ncbi.nlm.nih.gov/pubmed/20928887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.265
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