Improved functional overview of protein complexes using inferred epistatic relationships

BACKGROUND: Epistatic Miniarray Profiling(E-MAP) quantifies the net effect on growth rate of disrupting pairs of genes, often producing phenotypes that may be more (negative epistasis) or less (positive epistasis) severe than the phenotype predicted based on single gene disruptions. Epistatic intera...

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Autores principales: Ryan, Colm, Greene, Derek, Guénolé, Aude, van Attikum, Haico, Krogan, Nevan J, Cunningham, Pádraig, Cagney, Gerard
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Methodology Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117733/
https://ncbi.nlm.nih.gov/pubmed/21605386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-5-80
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