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ClC-7 is a slowly voltage-gated 2Cl(−)/1H(+)-exchanger and requires Ostm1 for transport activity
Mutations in the ClC-7/Ostm1 ion transporter lead to osteopetrosis and lysosomal storage disease. Its lysosomal localization hitherto precluded detailed functional characterization. Using a mutated ClC-7 that reaches the plasma membrane, we now show that both the aminoterminus and transmembrane span...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3117652/ https://ncbi.nlm.nih.gov/pubmed/21527911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.137 |
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