LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation

The ubiquitous Epstein Barr virus (EBV) exploits human B-cell development to establish a persistent infection in ∼90% of the world population. Constitutive activation of NF-κB by the viral oncogene latent membrane protein 1 (LMP1) has an important role in persistence, but is a risk factor for EBV-as...

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Detalhes bibliográficos
Main Authors: Verweij, Frederik J, van Eijndhoven, Monique A J, Hopmans, Erik S, Vendrig, Tineke, Wurdinger, Tom, Cahir-McFarland, Ellen, Kieff, Elliott, Geerts, Dirk, van der Kant, Rik, Neefjes, Jacques, Middeldorp, Jaap M, Pegtel, D Michiel
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117644/
https://ncbi.nlm.nih.gov/pubmed/21527913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.123
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