Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor

Understanding the genetic, structural, and biophysical mechanisms that caused protein functions to evolve is a central goal of molecular evolutionary studies. Ancestral sequence reconstruction (ASR) offers an experimental approach to these questions. Here we use ASR to shed light on the earliest fun...

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Detaylı Bibliyografya
Asıl Yazarlar: Carroll, Sean Michael, Ortlund, Eric A., Thornton, Joseph W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116920/
https://ncbi.nlm.nih.gov/pubmed/21698144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002117
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