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Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor

Understanding the genetic, structural, and biophysical mechanisms that caused protein functions to evolve is a central goal of molecular evolutionary studies. Ancestral sequence reconstruction (ASR) offers an experimental approach to these questions. Here we use ASR to shed light on the earliest fun...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Carroll, Sean Michael, Ortlund, Eric A., Thornton, Joseph W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116920/
https://ncbi.nlm.nih.gov/pubmed/21698144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002117
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