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Amino Acid Substitutions at the Major Insertion Loop of Candida albicans Sterol 14alpha-Demethylase Are Involved in Fluconazole Resistance

BACKGROUND: In the fungal pathogen Candida albicans, amino acid substitutions of 14alpha-demethylase (CaErg11p, CaCYP51) are associated with azole antifungals resistance. This is an area of research which is very dynamic, since the stakes concern the screening of new antifungals which circumvent res...

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Autori principali: Alvarez-Rueda, Nidia, Fleury, Audrey, Morio, Florent, Pagniez, Fabrice, Gastinel, Louis, Le Pape, Patrice
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116904/
https://ncbi.nlm.nih.gov/pubmed/21698128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021239
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