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Reagents for Astatination of Biomolecules. 5. Evaluation of hydrazone linkers in (211)At- and (125)I-labeled closo-decaborate(2-) conjugates of Fab′ as a means of decreasing kidney retention

Evaluation of monoclonal antibody (MAb) fragments (e.g. Fab′, Fab or engineered fragments) as cancer-targeting reagents for therapy with the α-particle emitting radionuclide astatine-211 ((211)At) has been hampered by low in vivo stability of the label and a propensity of these proteins localize to...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wilbur, D. Scott, Chyan, Ming-Kuan, Hamlin, Donald K., Nguyen, Holly, Vessella, Robert L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3116028/
https://ncbi.nlm.nih.gov/pubmed/21513347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc1005625
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