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Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse

Etoposide, a topoisomerase II inhibitor widely used in cancer therapy, is suspected of inducing secondary tumors and affecting the genetic constitution of germ cells. A better understanding of the potential heritable risk of etoposide is needed to provide sound genetic counseling to cancer patients...

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Detalhes bibliográficos
Main Authors: Marchetti, Francesco, Bishop, Jack B., Lowe, Xiu, Generoso, Walderico M., Hozier, John, Wyrobek, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC31160/
https://ncbi.nlm.nih.gov/pubmed/11274416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.061404598
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