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MCAK regulates chromosome alignment but is not necessary for preventing aneuploidy in mouse oocyte meiosis I
Errors in chromosome segregation in mammalian oocytes lead to aneuploid eggs that are developmentally compromised. In mitotic cells, mitotic centromere associated kinesin (MCAK; KIF2C) prevents chromosome segregation errors by detaching incorrect microtubule-kinetochore interactions. Here, we examin...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Company of Biologists
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882132/ https://ncbi.nlm.nih.gov/pubmed/20504960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.048306 |
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