Visualization of oligonucleotide probes and point mutations in interphase nuclei and DNA fibers using rolling circle DNA amplification

Rolling circle amplification (RCA) is a surface-anchored DNA replication reaction that can be exploited to visualize single molecular recognition events. Here we report the use of RCA to visualize target DNA sequences as small as 50 nts in peripheral blood lymphocytes or in stretched DNA fibers. Thr...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Zhong, Xiao-bo, Lizardi, Paul M., Huang, Xiao-hua, Bray-Ward, Patricia L., Ward, David C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31158/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274414/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.061026198
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