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Reduced Cardiac Remodeling and Function in Cardiac-Specific EP4 Receptor Knock-Out Mice with Myocardial Infarction

We have previously shown that: 1) COX-2 inhibition reduces cardiac hypertrophy and fibrosis post myocardial infarction (MI) in a mouse model; and 2) prostaglandin E(2) stimulates cardiomyocyte hypertrophy in vitro through its EP4 receptor. Since the role of cardiac myocyte EP4 in cardiac function an...

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Bibliografiske detaljer
Main Authors: Qian, Jian-Yong, Harding, Pamela, Liu, Yunhe, Shesely, Ed, Yang, Xiao-Ping, LaPointe, Margot C.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115709/
https://ncbi.nlm.nih.gov/pubmed/18180401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.107.102590
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