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Reduced Cardiac Remodeling and Function in Cardiac-Specific EP4 Receptor Knock-Out Mice with Myocardial Infarction
We have previously shown that: 1) COX-2 inhibition reduces cardiac hypertrophy and fibrosis post myocardial infarction (MI) in a mouse model; and 2) prostaglandin E(2) stimulates cardiomyocyte hypertrophy in vitro through its EP4 receptor. Since the role of cardiac myocyte EP4 in cardiac function an...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3115709/ https://ncbi.nlm.nih.gov/pubmed/18180401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.107.102590 |
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