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Prostaglandin E2 Increases Cardiac Fibroblast Proliferation and Increases Cyclin D Expression via EP1 Receptor

PGE(2) affects growth of many cell types. Thus, we hypothesized that PGE(2) would stimulate growth of cardiac fibroblasts. To test our hypothesis we used neonatal rat ventricular fibroblasts (NVF). RT-PCR demonstrated the presence of all 4 PGE(2) receptor (EPs) mRNAs in NVF. Using flow cytometry, we...

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Detalhes bibliográficos
Main Authors: Harding, Pamela, LaPointe, Margot C
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071899/
https://ncbi.nlm.nih.gov/pubmed/21342756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.plefa.2011.01.003
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